ZFP36 (ZFP36 ring finger protein) - Rat Genome Database
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Gene: ZFP36 (ZFP36 ring finger protein) Homo sapiens
Analyze
Symbol: ZFP36
Name: ZFP36 ring finger protein
RGD ID: 737182
HGNC Page HGNC
Description: Exhibits several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to lipid; and regulation of gene expression. Localizes to several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and ribonucleoprotein complex. Colocalizes with Dcp1-Dcp2 complex and RISC-loading complex; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G0/G1 switch regulatory protein 24; G0S24; GOS24; growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; NUP475; RNF162A; TIS11; tristetraprolin; tristetraproline; TTP; zfp-36; zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog; zinc finger protein, C3H type, 36 homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1939,406,847 - 39,409,412 (+)EnsemblGRCh38hg38GRCh38
GRCh381939,406,847 - 39,409,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,897,487 - 39,900,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,589,327 - 44,591,885 (+)NCBINCBI36hg18NCBI36
Build 341944,589,326 - 44,591,885NCBI
Celera1936,699,177 - 36,701,735 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1936,344,174 - 36,346,739 (+)NCBIHuRef
CHM1_11939,898,190 - 39,900,755 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP,ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
afimoxifene  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arachidonic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
belinostat  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (EXP)
cisplatin  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
diethyl maleate  (EXP)
dimethyl sulfoxide  (EXP)
disodium selenite  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ferric oxide  (ISO)
fluoranthene  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gentamycin  (EXP,ISO)
hemin  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
indometacin  (EXP)
isoeugenol  (EXP)
ketamine  (ISO)
KT 5720  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP,ISO)
Niclosamide  (EXP)
nicotine  (EXP,ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propanal  (EXP)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
succimer  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tobramycin  (EXP)
topotecan  (ISO)
toxaphene  (ISO)
trans-isoeugenol  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (IDA,IEA,IMP)
3'-UTR-mediated mRNA stabilization  (IDA)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to fibroblast growth factor stimulus  (IDA,IEA)
cellular response to glucocorticoid stimulus  (IDA)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (IDA)
cellular response to lipopolysaccharide  (IDA,IEA,IMP)
cellular response to tumor necrosis factor  (IDA,IEA)
intracellular signal transduction  (ISO)
MAPK cascade  (IMP,ISS)
miRNA mediated inhibition of translation  (IEA,ISS)
mRNA catabolic process  (IDA)
mRNA transport  (IMP)
negative regulation of erythrocyte differentiation  (IDA)
negative regulation of inflammatory response  (IEA)
negative regulation of interleukin-2 production  (IEA,ISS)
negative regulation of myeloid cell differentiation  (IEA)
negative regulation of polynucleotide adenylyltransferase activity  (IEA,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,IMP)
negative regulation of viral transcription  (IMP)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IDA)
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  (IDA)
nuclear-transcribed mRNA poly(A) tail shortening  (IEA,IMP)
p38MAPK cascade  (IEA,ISS)
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  (IDA)
positive regulation of fat cell differentiation  (IEA,ISS)
positive regulation of gene silencing by miRNA  (IMP)
positive regulation of intracellular mRNA localization  (IMP)
positive regulation of mRNA catabolic process  (ISO)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IDA,IEA,ISS)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (IDA,IEA)
regulation of keratinocyte apoptotic process  (IMP)
regulation of keratinocyte differentiation  (IMP)
regulation of keratinocyte proliferation  (IMP)
regulation of mRNA stability  (IDA,IMP,TAS)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tumor necrosis factor production  (IDA)
response to starvation  (IDA)
response to wounding  (IDA,IEA,ISS)
RNA destabilization  (ISO)
viral process  (IEA)

Cellular Component

References

Additional References at PubMed
PMID:1699942   PMID:2062660   PMID:2204625   PMID:7768935   PMID:8422274   PMID:8478004   PMID:9703499   PMID:9828130   PMID:10330172   PMID:10751406   PMID:11279239   PMID:11719186  
PMID:11748221   PMID:11782475   PMID:11886850   PMID:12115244   PMID:12198173   PMID:12440952   PMID:12477932   PMID:12515557   PMID:12578825   PMID:12578839   PMID:12639954   PMID:12646273  
PMID:12705825   PMID:12748283   PMID:12751757   PMID:12754205   PMID:12823857   PMID:14604009   PMID:14679154   PMID:14688255   PMID:14766228   PMID:15014438   PMID:15067324   PMID:15117938  
PMID:15170914   PMID:15187092   PMID:15187101   PMID:15231747   PMID:15280467   PMID:15489334   PMID:15504035   PMID:15535838   PMID:15634918   PMID:15687258   PMID:15766526   PMID:15778452  
PMID:16126846   PMID:16189514   PMID:16262601   PMID:16364915   PMID:16546352   PMID:16596264   PMID:16614304   PMID:16820934   PMID:16935542   PMID:17170118   PMID:17369404   PMID:17517366  
PMID:17546847   PMID:17599736   PMID:17606294   PMID:17855506   PMID:17893259   PMID:18029348   PMID:18250465   PMID:18326031   PMID:18367721   PMID:18536977   PMID:18814951   PMID:19258311  
PMID:19363120   PMID:19654331   PMID:19697322   PMID:19738286   PMID:19962963   PMID:19995385   PMID:20038433   PMID:20042592   PMID:20157568   PMID:20166898   PMID:20211142   PMID:20221403  
PMID:20335167   PMID:20498646   PMID:20691152   PMID:20702587   PMID:20828164   PMID:21078877   PMID:21278925   PMID:21507959   PMID:21593445   PMID:21606497   PMID:21611196   PMID:21656745  
PMID:21775632   PMID:21784977   PMID:21818148   PMID:21830391   PMID:21832049   PMID:21873635   PMID:21875902   PMID:21964062   PMID:22094256   PMID:22138182   PMID:22203041   PMID:22203679  
PMID:22210895   PMID:22268119   PMID:22387927   PMID:22426177   PMID:22428029   PMID:22433566   PMID:22452791   PMID:22544323   PMID:22658674   PMID:22700982   PMID:22863009   PMID:22865915  
PMID:22907529   PMID:22918951   PMID:22960231   PMID:22968621   PMID:23030431   PMID:23102618   PMID:23212617   PMID:23241166   PMID:23269677   PMID:23349315   PMID:23401122   PMID:23525947  
PMID:23583445   PMID:23595149   PMID:23644599   PMID:23744329   PMID:24150491   PMID:24253039   PMID:24401661   PMID:24705354   PMID:24737323   PMID:24780075   PMID:24978456   PMID:25038453  
PMID:25043949   PMID:25056949   PMID:25106868   PMID:25111853   PMID:25452305   PMID:25604244   PMID:25724669   PMID:25762736   PMID:25832634   PMID:25939870   PMID:25943894   PMID:25955820  
PMID:26062599   PMID:26125882   PMID:26356262   PMID:26370510   PMID:26486958   PMID:26497679   PMID:26517838   PMID:26546680   PMID:26551835   PMID:26563146   PMID:26644407   PMID:26673895  
PMID:26820662   PMID:26840564   PMID:27074834   PMID:27107012   PMID:27182009   PMID:27193233   PMID:27265729   PMID:27424080   PMID:27825143   PMID:27840917   PMID:28119310   PMID:28287161  
PMID:28302726   PMID:28410208   PMID:28539664   PMID:28724967   PMID:29124478   PMID:29246442   PMID:29395067   PMID:29444957   PMID:29570932   PMID:29577897   PMID:29728635   PMID:29936792  
PMID:30311568   PMID:30380668   PMID:30420441   PMID:30639474   PMID:30650008   PMID:30852628   PMID:30917308   PMID:30945288   PMID:31046669   PMID:31660029   PMID:31668919   PMID:31679460  
PMID:31817224   PMID:32039742   PMID:32296183   PMID:32814053  


Genomics

Comparative Map Data
ZFP36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1939,406,847 - 39,409,412 (+)EnsemblGRCh38hg38GRCh38
GRCh381939,406,847 - 39,409,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,897,487 - 39,900,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,589,327 - 44,591,885 (+)NCBINCBI36hg18NCBI36
Build 341944,589,326 - 44,591,885NCBI
Celera1936,699,177 - 36,701,735 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1936,344,174 - 36,346,739 (+)NCBIHuRef
CHM1_11939,898,190 - 39,900,755 (+)NCBICHM1_1
Zfp36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,076,209 - 28,078,653 (-)NCBIGRCm39mm39
GRCm38728,376,784 - 28,379,228 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,376,784 - 28,380,253 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,161,803 - 29,164,247 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,085,544 - 28,087,988 (-)NCBImm8
Celera722,938,422 - 22,940,866 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.72NCBI
Zfp36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0185,380,088 - 85,382,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,380,088 - 85,382,569 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,595,418 - 86,597,898 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,486,643 - 83,489,123 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,564,759 - 83,567,219 (-)NCBI
Celera178,065,353 - 78,067,833 (-)NCBICelera
Cytogenetic Map1q21NCBI
Zfp36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468152,744 - 155,140 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468152,744 - 155,140 (-)NCBIChiLan1.0ChiLan1.0
ZFP36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11945,052,797 - 45,055,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,052,801 - 45,055,390 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01936,505,056 - 36,507,693 (+)NCBIMhudiblu_PPA_v0panPan3
ZFP36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1113,816,273 - 113,818,065 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11113,815,972 - 113,818,093 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Zfp36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366612,251,148 - 2,253,527 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFP36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,052,137 - 48,066,257 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,063,732 - 48,066,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,677,781 - 143,680,284 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFP36
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,011,073 - 34,013,665 (+)NCBI
ChlSab1.1 Ensembl634,011,031 - 34,013,870 (+)Ensembl
Zfp36
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,732,222 - 12,738,006 (+)NCBI

Position Markers
STS-H28008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,792 - 39,900,024UniSTSGRCh37
Build 361944,591,632 - 44,591,864RGDNCBI36
Celera1936,701,482 - 36,701,714RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,346,479 - 36,346,711UniSTS
GeneMap99-GB4 RH Map19235.07UniSTS
NCBI RH Map19420.3UniSTS
RH81038  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,886 - 39,900,026UniSTSGRCh37
Build 361944,591,726 - 44,591,866RGDNCBI36
Celera1936,701,576 - 36,701,716RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,346,573 - 36,346,713UniSTS
RH80286  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,336 - 39,899,564UniSTSGRCh37
Build 361944,591,176 - 44,591,404RGDNCBI36
Celera1936,701,026 - 36,701,254RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,346,023 - 36,346,251UniSTS
GeneMap99-GB4 RH Map19236.79UniSTS
D19S633E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,773 - 39,899,908UniSTSGRCh37
Build 361944,591,613 - 44,591,748RGDNCBI36
Celera1936,701,463 - 36,701,598RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,346,460 - 36,346,595UniSTS
PMC321570P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,198 - 39,899,612UniSTSGRCh37
Build 361944,591,038 - 44,591,452RGDNCBI36
Celera1936,700,888 - 36,701,302RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,345,885 - 36,346,299UniSTS
ZFP36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,784 - 39,899,908UniSTSGRCh37
Build 361944,591,624 - 44,591,748RGDNCBI36
Celera1936,701,474 - 36,701,598RGD
HuRef1936,346,471 - 36,346,595UniSTS
STS-M92843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371939,899,547 - 39,899,769UniSTSGRCh37
Build 361944,591,387 - 44,591,609RGDNCBI36
Celera1936,701,237 - 36,701,459RGD
Cytogenetic Map19q13.1UniSTS
HuRef1936,346,234 - 36,346,456UniSTS
GeneMap99-GB4 RH Map19235.41UniSTS
NCBI RH Map19420.3UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR346hsa-miR-346Mirtarbaseexternal_infoWestern blot;qRT-PCR;OtherFunctional MTI21611196
MIR346hsa-miR-346Tarbaseexternal_infoqPCRPOSITIVE
MIR346hsa-miR-346Tarbaseexternal_infoWesternblitPOSITIVE
MIR346hsa-miR-346Tarbaseexternal_infoOtherPOSITIVE
MIR29Ahsa-miR-29a-3pMirecordsexternal_infoNANA19247375

Predicted Target Of
Summary Value
Count of predictions:1684
Count of miRNA genes:660
Interacting mature miRNAs:733
Transcripts:ENST00000248673, ENST00000594045, ENST00000594442, ENST00000597629, ENST00000600033
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 484 738 286 26 200 14 1318 221 410 25 211 624 13 693 791
Medium 1945 2241 1435 595 1745 449 3002 1952 2986 388 1213 946 157 511 1997 3
Low 3 5 2 1 3 1 34 20 312 5 24 38 1 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000594045   ⟹   ENSP00000472329
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,406,857 - 39,408,179 (+)Ensembl
RefSeq Acc Id: ENST00000594442   ⟹   ENSP00000471239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,406,847 - 39,409,412 (+)Ensembl
RefSeq Acc Id: ENST00000597629   ⟹   ENSP00000469647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,406,847 - 39,409,407 (+)Ensembl
RefSeq Acc Id: ENST00000600033
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,407,439 - 39,408,143 (+)Ensembl
RefSeq Acc Id: ENST00000652583
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1939,406,858 - 39,409,368 (+)Ensembl
RefSeq Acc Id: NM_003407   ⟹   NP_003398
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,406,847 - 39,409,407 (+)NCBI
GRCh371939,897,487 - 39,900,052 (+)NCBI
Build 361944,589,327 - 44,591,885 (+)NCBI Archive
HuRef1936,344,174 - 36,346,739 (+)NCBI
CHM1_11939,898,190 - 39,900,755 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003398   ⟸   NM_003407
- Sequence:
RefSeq Acc Id: ENSP00000471239   ⟸   ENST00000594442
RefSeq Acc Id: ENSP00000469647   ⟸   ENST00000597629
RefSeq Acc Id: ENSP00000472329   ⟸   ENST00000594045
Protein Domains
C3H1-type

Promoters
RGD ID:7239905
Promoter ID:EPDNEW_H25698
Type:initiation region
Name:ZFP36_1
Description:ZFP36 ring finger protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381939,406,847 - 39,406,907EPDNEW
RGD ID:6814663
Promoter ID:HG_XEF:4065
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid
Transcripts:NM_001009765,   NM_011756,   NM_133290,   NM_174493
Position:
Human AssemblyChrPosition (strand)Source
Build 361944,590,126 - 44,591,212 (+)MPROMDB
RGD ID:6853660
Promoter ID:EP36012
Type:single initiation site
Name:HS_ZFP36
Description:Zinc finger transcriptional regulator gene, ZFP36 or TIS11Aor TTP gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 210; Mammalian tristetraproline.
Tissues & Cell Lines:lymphocytes, [G0/G1]
Experiment Methods:Sequencing of a full-length cDNA; Primer extension with homologous sequence ladder
Position:No map positions available.

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.12-13.2(chr19:37319377-42738688)x3 copy number gain See cases [RCV000050636] Chr19:37319377..42738688 [GRCh38]
Chr19:37810279..43242840 [GRCh37]
Chr19:42502119..47934680 [NCBI36]
Chr19:19q13.12-13.2
pathogenic
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh37/hg19 19q13.12-13.2(chr19:37582250-41630908)x3 copy number gain See cases [RCV000239839] Chr19:37582250..41630908 [GRCh37]
Chr19:19q13.12-13.2
pathogenic
GRCh37/hg19 19q13.2(chr19:39879621-39944079)x3 copy number gain Ductal breast carcinoma [RCV000207258] Chr19:39879621..39944079 [GRCh37]
Chr19:19q13.2
uncertain significance
GRCh37/hg19 19q13.2(chr19:39888449-39903088)x0 copy number loss not provided [RCV000752679] Chr19:39888449..39903088 [GRCh37]
Chr19:19q13.2
benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_003407.5(ZFP36):c.109C>T (p.Pro37Ser) single nucleotide variant not provided [RCV000967513] Chr19:39407827 [GRCh38]
Chr19:39898467 [GRCh37]
Chr19:19q13.2
benign
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12862 AgrOrtholog
COSMIC ZFP36 COSMIC
Ensembl Genes ENSG00000128016 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000469647 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000471239 UniProtKB/TrEMBL
  ENSP00000472329 UniProtKB/TrEMBL
Ensembl Transcript ENST00000594045 UniProtKB/TrEMBL
  ENST00000594442 UniProtKB/TrEMBL
  ENST00000597629 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000128016 GTEx
HGNC ID HGNC:12862 ENTREZGENE
Human Proteome Map ZFP36 Human Proteome Map
InterPro Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7538 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7538 ENTREZGENE
OMIM 190700 OMIM
Pfam zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37451 PharmGKB
PROSITE ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF90229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0QY76_HUMAN UniProtKB/TrEMBL
  M0R252_HUMAN UniProtKB/TrEMBL
  P26651 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RA54 UniProtKB/Swiss-Prot
  M0R0H3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-04 ZFP36  ZFP36 ring finger protein    zinc finger protein 36, C3H type, homolog (mouse)  Symbol and/or name change 5135510 APPROVED