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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620707
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tff1
Name: trefoil factor 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tff1increases expressionISOTFF1 (Homo sapiens)6480464CTDGenistein results in increased expression of TFF1 mRNA; Genistein results in increased expression of TFF1 proteinPMID:11331657 PMID:11368622 PMID:15090535 PMID:16474171 PMID:22562034 PMID:23384675 PMID:24284790 PMID:35307500
Tff1multiple interactionsISOTFF1 (Homo sapiens)6480464CTDESR1 protein inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]; fulvestrant inhibits the reaction [Genistein results in increased expression of TFF1 mRNA]PMID:22562034 PMID:23384675
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