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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620692
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xiap
Name: X-linked inhibitor of apoptosis
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xiapincreases expressionISOXIAP (Homo sapiens)6480464CTDNicotine results in increased expression of XIAP mRNA; Nicotine results in increased expression of XIAP proteinPMID:16601104 PMID:18676776 PMID:20727180 PMID:21267677 PMID:30259641
Xiapmultiple interactionsISOXIAP (Homo sapiens)6480464CTD[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]PMID:16601104 PMID:20727180 PMID:30259641
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