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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620598
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox1
Name: NADPH oxidase 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox1increases expressionEXP 6480464CTDGlyphosate results in increased expression of NOX1 mRNA; Glyphosate results in increased expression of NOX1 proteinPMID:34906888
Nox1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [Glyphosate results in increased expression of NOX1 protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of CAT protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of CLDN1 protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of GJA1 protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of GPX1 protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of OCLN protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of SOD2 protein]; NOX1 protein affects the reaction [Glyphosate results in decreased expression of TJP1 protein]PMID:34906888
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