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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620538
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1r14c
Name: protein phosphatase 1, regulatory (inhibitor) subunit 14c
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r14cdecreases expressionISOPPP1R14C (Homo sapiens)6480464CTDCalcitriol results in decreased expression of PPP1R14C mRNAPMID:21592394
Ppp1r14cincreases expressionISOPPP1R14C (Homo sapiens)6480464CTDCalcitriol results in increased expression of PPP1R14C mRNAPMID:26485663
Ppp1r14cmultiple interactionsISOPPP1R14C (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in decreased expression of PPP1R14C mRNAPMID:21592394
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