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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620536
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp1r14a
Name: protein phosphatase 1, regulatory (inhibitor) subunit 14A
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp1r14aincreases expressionISOPpp1r14a (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of PPP1R14A mRNAPMID:22228805
Ppp1r14aincreases methylationISOPPP1R14A (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of PPP1R14A 5' UTR; Benzo(a)pyrene results in increased methylation of PPP1R14A promoterPMID:27901495
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