Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	62052
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnni3
Name:	troponin I3, cardiac type

Acc ID:	CHEBI:4027
Term:	cyclophosphamide
Definition:	A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID:	MESH:D003520

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnni3	increases expression	EXP		6480464	CTD	Cyclophosphamide results in increased expression of TNNI3 protein	PMID:35762198
Tnni3	multiple interactions	EXP		6480464	CTD	Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]	PMID:35762198
Tnni3	increases expression	ISO	Tnni3 (Mus musculus)	6480464	CTD	Cyclophosphamide results in increased expression of TNNI3 protein	PMID:38278497
Tnni3	increases expression	ISO	TNNI3 (Homo sapiens)	6480464	CTD	Cyclophosphamide results in increased expression of TNNI3 protein	PMID:17562616 PMID:18548196
Tnni3	multiple interactions	ISO	Tnni3 (Mus musculus)	6480464	CTD	Fenofibrate inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]; levocabastine inhibits the reaction [Cyclophosphamide results in increased expression of TNNI3 protein]	PMID:38278497

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