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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Acc ID: CHEBI:75404
Term: tyrphostin AG 1478
Definition: A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
Chemical ID: MESH:C101044
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb4multiple interactionsISOErbb4 (Mus musculus)6480464CTDRTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ERBB4 mRNA]]PMID:35716406
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