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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTD[Troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA; Troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]PMID:20847119
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