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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620465
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:61049
Term: tacrolimus (anhydrous)
Definition: A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4decreases expression EXP 151893463RGDtacrolimus co-treated with plerixafor decreases expression of CXCR4 protein in liver 
Cxcr4increases expression EXP 151893463RGDtacrolimus increases expression of CXCR4 protein in liver 
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