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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bdkrb1
Name: bradykinin receptor B1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdkrb1multiple interactionsEXP 6480464CTD[HOE 140, desArg(10)- binds to and results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to StreptozocinPMID:17989505
Bdkrb1increases expressionISOBdkrb1 (Mus musculus)6480464CTDStreptozocin results in increased expression of BDKRB1 mRNAPMID:19516248
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