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GENE - TERM ANNOTATION REPORT

RGD ID: 620396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kl
Name: Klotho
Acc ID: DOID:12466
Term: secondary hyperparathyroidism
Definition: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Definition Source(s): MESH:D006962
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kl IEP 10403078RGDassociated with Uremia;mRNA,protein:increased expression:parathyroid gland: 
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