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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4multiple interactionsEXP 6480464CTD[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 proteinPMID:17640958 PMID:24384915
Abcc4multiple interactionsISOAbcc4 (Mus musculus)6480464CTD[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABCC4 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 protein; LEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]; LEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]; RXRA affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]PMID:18952117 PMID:20938992 PMID:24384915 PMID:33549593
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