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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1decreases expression EXP 329853763RGDSB203580 decreases expression of protein in oxygen-glucose deprived rat neuronal PC12 cells 
Becn1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [decamethrin results in increased expression of BECN1 protein]; SB 203580 inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in decreased expression of BECN1 protein]]PMID:26588882 PMID:37769856
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [Calcitriol results in increased activity of BECN1 mRNA]PMID:19748465
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