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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDvorinostat results in increased expression of BECN1 proteinPMID:17881280 PMID:20543569
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [vorinostat results in increased expression of BECN1 protein]; BECN1 protein promotes the reaction [vorinostat results in increased cleavage of MAP1LC3B protein]PMID:17881280 PMID:20543569
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