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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdx3
Name: peroxiredoxin 3
Acc ID: CHEBI:2922
Term: auranofin
Definition: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.
Chemical ID: MESH:D001310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdx3increases oxidationEXP 6480464CTDAuranofin results in increased oxidation of PRDX3 proteinPMID:26975474
Prdx3multiple interactionsEXP 6480464CTDCyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]PMID:26975474
Prdx3increases oxidationISOPRDX3 (Homo sapiens)6480464CTDAuranofin results in increased oxidation of PRDX3 proteinPMID:18789312 PMID:26975474
Prdx3increases oxidationISOPrdx3 (Mus musculus)6480464CTDAuranofin results in increased oxidation of PRDX3 proteinPMID:18789312
Prdx3multiple interactionsISOPRDX3 (Homo sapiens)6480464CTDAuranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]PMID:21355852
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