Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dcxr
Name: dicarbonyl and L-xylulose reductase
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dcxrdecreases activityISODCXR (Homo sapiens)6480464CTDVitamin K 3 results in decreased activity of DCXR proteinPMID:28595002
Dcxrincreases metabolic processingISODCXR (Homo sapiens)6480464CTDDCXR protein results in increased metabolism of Vitamin K 3PMID:28595002
Dcxrmultiple interactionsISODCXR (Homo sapiens)6480464CTD[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Hydrogen Peroxide; [DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; [Vitamin K 3 co-treated with NADP] binds to DCXR protein; CAT protein inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Hydrogen Peroxide]; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]; Vitamin K 3 inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]PMID:25526675 PMID:28595002
Go Back to source page   Continue to Ontology report