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GENE - TERM ANNOTATION REPORT

RGD ID: 62002
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
Acc ID: DOID:9007428
Term: Muscle Spasticity
Definition: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a 'free interval') followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
Definition Source(s): MESH:D009128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ywhag ISOYWHAG (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: SpasticityPMID:25741868 PMID:28492532 PMID:31926053
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