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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62002
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ywhagincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of YWHAG proteinPMID:30636491
Ywhagmultiple interactionsEXP 6480464CTDQuercetin promotes the reaction [Doxorubicin results in increased expression of YWHAG protein]; YWHAG protein promotes the reaction [Quercetin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; YWHAG protein promotes the reaction [Quercetin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]]PMID:30636491
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