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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620007
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2j4
Name: cytochrome P450, family 2, subfamily j, polypeptide 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2j4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP2J4 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CYP2J9 mRNAPMID:16984957 PMID:20959002 PMID:21215274 PMID:32387183
Cyp2j4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2J4 mRNAPMID:32109520
Cyp2j4affects expressionISOCyp2j9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CYP2J9 mRNAPMID:26377647
Cyp2j4decreases expressionISOCyp2j9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CYP2J9 mRNAPMID:28213091
Cyp2j4increases expressionISOCYP2J2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2J2 mRNAPMID:19619570 PMID:21632981 PMID:26238291
Cyp2j4increases expressionISOCyp2j9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CYP2J9 mRNAPMID:16960034 PMID:19465110
Cyp2j4multiple interactionsISOCYP2J2 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP2J2 mRNAPMID:19619570
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