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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionEXP 6480464CTDSildenafil Citrate results in increased expression of VEGFA mRNA; Sildenafil Citrate results in increased expression of VEGFA proteinPMID:18373738 PMID:20583517
Vegfamultiple interactionsEXP 6480464CTDSildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein]; Sildenafil Citrate inhibits the reaction [Aflatoxin B1 results in increased expression of VEGFA mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]; Sildenafil Citrate inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA protein]PMID:30974023 PMID:32959702 PMID:35608386
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