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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects expressionEXP 6480464CTDZearalenone affects the expression of ABCB1A proteinPMID:22521637
Abcb1adecreases expressionEXP 6480464CTDZearalenone results in decreased expression of ABCB1A mRNAPMID:23707492 PMID:29627501
Abcb1aincreases expressionEXP 6480464CTDZearalenone results in increased expression of ABCB1 mRNA; Zearalenone results in increased expression of ABCB1A mRNAPMID:20607812 PMID:22521637 PMID:23707492
Abcb1amultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCB1A mRNA]PMID:23707492
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