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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Defb1
Name: defensin beta 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Defb1affects methylationISODEFB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of DEFB1 5' UTRPMID:27901495
Defb1increases expressionISODefb1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of DEFB1 mRNAPMID:19770486 PMID:21964900
Defb1increases expressionISODEFB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of DEFB1 mRNAPMID:20106945 PMID:32234424
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