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Gene: Defb1 (defensin beta 1) Mus musculus
Symbol: Defb1
Name: defensin beta 1
Description: Involved in innate immune response and response to bacterium. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and lung disease. Is expressed in epidermis and skin. Orthologous to human DEFB1 (defensin beta 1); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW260221; BD-1; beta-defensin 1; defensin, beta 1; mBD-1
Homo sapiens (human) : DEFB1 (defensin beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Defb1 (defensin beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004444 (beta-defensin 1-like)
Pan paniscus (bonobo/pygmy chimpanzee) : DEFB1 (defensin beta 1)
Canis lupus familiaris (dog) : DEFB1 (defensin beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Defb1 (defensin beta 1)
Sus scrofa (pig) : DEFB1 (defensin beta 1)
Chlorocebus sabaeus (green monkey) : DEFB1 (defensin beta 1)
Heterocephalus glaber (naked mole-rat) : Defb1 (defensin beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl821,776,599 - 21,795,185 (+)Ensembl
GRCm38821,776,555 - 21,795,185 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37822,887,027 - 22,905,657 (+)NCBIGRCm37mm9NCBIm37
MGSCv36823,242,144 - 23,260,730 (+)NCBImm8
Celera823,268,826 - 23,284,384 (+)NCBICelera
Cytogenetic Map8 A2NCBI
cM Map810.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Defb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732690
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.