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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619894
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pln
Name: phospholamban
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plndecreases phosphorylationEXP 6480464CTDIsoproterenol results in decreased phosphorylation of PLN proteinPMID:16723803 PMID:17509559
Plnincreases phosphorylationEXP 6480464CTDIsoproterenol results in increased phosphorylation of PLN proteinPMID:21268078
Plnmultiple interactionsEXP 6480464CTDastragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]; candesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein]; Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein; Propranolol inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased phosphorylation of PLN protein]PMID:10997724 PMID:16723803 PMID:17509559
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