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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smpd3
Name: sphingomyelin phosphodiesterase 3
Acc ID: CHEBI:75998
Term: trametinib
Definition: A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.
Chemical ID: MESH:C560077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smpd3multiple interactionsISOSMPD3 (Homo sapiens)6480464CTD[sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of SMPD3 mRNAPMID:36139627
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