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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61893
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkp
Name: phosphofructokinase, platelet
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkpincreases expressionEXP 6480464CTDEndosulfan results in increased expression of PFKP mRNAPMID:29391264
Pfkpincreases expressionISOPFKP (Homo sapiens)6480464CTDEndosulfan results in increased expression of PFKP proteinPMID:36753968
Pfkpmultiple interactionsISOPFKP (Homo sapiens)6480464CTD[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of PFKP mRNA; [Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of PFKP proteinPMID:26159488 PMID:36753968
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