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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k2decreases phosphorylationEXP 6480464CTDsorafenib results in decreased phosphorylation of MAP2K2 proteinPMID:17341847
Map2k2decreases phosphorylationISOMAP2K2 (Homo sapiens)6480464CTDsorafenib results in decreased phosphorylation of MAP2K2 proteinPMID:17341847 PMID:18200035
Map2k2multiple interactionsISOMAP2K2 (Homo sapiens)6480464CTD[sorafenib co-treated with PI103] inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K2 protein]; sorafenib inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K2 protein]PMID:21187475
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