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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
Acc ID: CHEBI:17336
Term: all-trans-retinol
Definition: A retinol in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014801
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k2increases phosphorylationEXP 6480464CTDVitamin A results in increased phosphorylation of MAP2K2 proteinPMID:16510265
Map2k2multiple interactionsEXP 6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]; AG 1879 inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]; Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein]PMID:16510265
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