GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr2b | increases activity | ISO | Htr2b (Mus musculus) | 6480464 | CTD | Fluoxetine results in increased activity of HTR2B protein | PMID:18758753 | Htr2b | increases expression | ISO | Htr2b (Mus musculus) | 6480464 | CTD | Fluoxetine results in increased expression of HTR2B mRNA | PMID:21083617 | Htr2b | multiple interactions | ISO | Htr2b (Mus musculus) | 6480464 | CTD | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein; [[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein; [Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein; [Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein; [Fluoxetine results in increased expression of and results in increased activity of HTR2B protein] which results in increased metabolism of Glycogen; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; Fluoxetine binds to and results in increased activity of HTR2B protein; Fluoxetine promotes the reaction [mesulergine binds to HTR2B protein]; Fluoxetine results in increased expression of and results in increased activity of HTR2B protein; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]; HTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]; HTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein] | PMID:11930908 PMID:18758753 PMID:19662385 PMID:21320410 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |