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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tf
Name: transferrin
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfdecreases expressionEXP 6480464CTDCopper results in decreased expression of TF mRNAPMID:30556269
Tfincreases expressionEXP 6480464CTDCopper deficiency results in increased expression of TF proteinPMID:18993053
Tfmultiple interactionsEXP 6480464CTDCopper deficiency results in decreased expression of [Iron binds to TF protein]PMID:20164366
Tfaffects bindingISOTF (Homo sapiens)6480464CTDCopper binds to TF protein modified form; TF protein binds to CopperPMID:14534351 PMID:15359738 PMID:21792595 PMID:23896426
Tfmultiple interactionsISOTF (Homo sapiens)6480464CTD[triazacyclononane analog co-treated with Copper] binds to TF protein; Polysaccharides affects the reaction [Copper binds to TF protein modified form]PMID:21429825 PMID:21792595
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