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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3767
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sult1a1
Name: sulfotransferase family 1A member 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sult1a1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of SULT1A1 mRNAPMID:31119341 PMID:32145629
Sult1a1increases sulfationEXP 6480464CTDSULT1A1 protein results in increased sulfation of EstradiolPMID:11181495
Sult1a1affects sulfationISOSULT1A1 (Homo sapiens)6480464CTDSULT1A1 gene polymorphism affects the sulfation of EstradiolPMID:16517757
Sult1a1increases sulfationISOSULT1A1 (Homo sapiens)6480464CTDSULT1A1 protein results in increased sulfation of EstradiolPMID:11181495 PMID:16517757 PMID:17433394
Sult1a1multiple interactionsISOSULT1A1 (Homo sapiens)6480464CTD2,2',3,4,4',5',6-heptabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]; 4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]; [Estradiol co-treated with TGFB1 protein] results in decreased expression of SULT1A1 mRNA; Halogenated Diphenyl Ethers analog inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]; pentabrominated diphenyl ether 100 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; Pentachlorophenol inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tetrabromobisphenol A inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]; tribromodiphenyl ether 28 inhibits the reaction [[Estradiol co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of SULT1A1 protein]PMID:16601080 PMID:17433394 PMID:30165855
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