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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:90633
Term: perfluorododecanoic acid
Definition: A fluoroalkanoic acid that is dodecanoic acid in which all of the hydrogens attached to carbon atoms are replaced by fluorines. It is a highly persistent, bioaccumulative breakdown product of stain- and grease-proof coatings on food packaging, soft furnishings and carpets.
Chemical ID: MESH:C522391
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srd5a1affects expressionEXP 6480464CTDperfluorododecanoic acid affects the expression of SRD5A1 mRNAPMID:33774092
Srd5a1decreases activityEXP 6480464CTDperfluorododecanoic acid results in decreased activity of SRD5A1 proteinPMID:38574835
Srd5a1decreases activityISOSRD5A1 (Homo sapiens)6480464CTDperfluorododecanoic acid results in decreased activity of SRD5A1 proteinPMID:38574835
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