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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod1
Name: superoxide dismutase 1
Acc ID: CHEBI:6130
Term: ketorolac tromethamine
Definition: An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Chemical ID: MESH:D020911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod1decreases activityEXP 6480464CTDKetorolac Tromethamine results in decreased activity of SOD1 proteinPMID:37348669
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