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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3decreases expressionEXP 6480464CTDOxidopamine results in decreased expression of SLC6A3 mRNA; Oxidopamine results in decreased expression of SLC6A3 proteinPMID:15518916 PMID:20200117
Slc6a3increases expressionEXP 6480464CTDOxidopamine results in increased expression of SLC6A3 mRNA; Oxidopamine results in increased expression of SLC6A3 proteinPMID:15303306 PMID:34302886
Slc6a3increases response to substanceEXP 6480464CTDSLC6A3 protein results in increased susceptibility to OxidopaminePMID:10881039
Slc6a3increases secretionEXP 6480464CTDOxidopamine results in increased secretion of SLC6A3 proteinPMID:12929136
Slc6a3multiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [Oxidopamine results in increased expression of SLC6A3 protein]PMID:34302886
Slc6a3increases response to substanceISOSLC6A3 (Homo sapiens)6480464CTDSLC6A3 protein results in increased susceptibility to OxidopaminePMID:34252731
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