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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a4
Name: solute carrier family 6 member 4
Acc ID: CHEBI:63580
Term: ribavirin
Definition: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses.
Chemical ID: MESH:D012254
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a4increases expressionISOSLC6A4 (Homo sapiens)6480464CTDRibavirin results in increased expression of SLC6A4 mRNAPMID:16476009
Slc6a4multiple interactionsISOSLC6A4 (Homo sapiens)6480464CTDRibavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin results in increased expression of and results in increased activity of SLC6A4 proteinPMID:16476009
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