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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a4
Name: solute carrier family 6 member 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a4increases expressionEXP 6480464CTDEstradiol results in increased expression of SLC6A4 mRNAPMID:18650020 PMID:21382399
Slc6a4multiple interactionsEXP 6480464CTD[Estradiol co-treated with Fluoxetine] results in increased expression of SLC6A4 mRNA; [Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNA; Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]PMID:18650020 PMID:21382399
Slc6a4decreases expressionISOSLC6A4 (Homo sapiens)6480464CTDEstradiol results in decreased expression of SLC6A4 mRNAPMID:34748853
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