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GENE - TERM ANNOTATION REPORT

RGD ID: 3632
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Scn2a
Name: sodium voltage-gated channel alpha subunit 2
Acc ID: DOID:9007956
Term: Febrile Seizures
Definition: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
Definition Source(s): MESH:D003294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scn2a ISOSCN2A (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:25344690
Scn2a ISOSCN2A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Febrile seizures | ClinVar Annotator: match by term: febrile convulsionPMID:25741868 PMID:28492532
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