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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:17741
Term: N,N-dimethylformamide
Definition: A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.
Chemical ID: MESH:D004126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxradecreases degradationISORXRA (Homo sapiens)6480464CTDDimethylformamide results in decreased degradation of RXRA proteinPMID:31875996
Rxraincreases phosphorylationISORXRA (Homo sapiens)6480464CTD[Dimethylformamide results in increased phosphorylation of MAPK1 protein] which results in increased phosphorylation of RXRA protein; [Dimethylformamide results in increased phosphorylation of MAPK3 protein] which results in increased phosphorylation of RXRA proteinPMID:31875996
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTDAlitretinoin inhibits the reaction [Dimethylformamide results in decreased degradation of RXRA protein]; Dimethylformamide promotes the reaction [NFE2L2 protein binds to RXRA protein]; U 0126 inhibits the reaction [Dimethylformamide results in decreased degradation of RXRA protein]PMID:31875996
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