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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3602
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6
Name: ribosomal protein S6
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6decreases expressionEXP 6480464CTDEstradiol results in decreased expression of RPS6 mRNAPMID:32145629
Rps6increases expressionISORPS6 (Homo sapiens)6480464CTDEstradiol results in increased expression of RPS6 mRNAPMID:11179685
Rps6increases phosphorylationISORPS6 (Homo sapiens)6480464CTDEstradiol results in increased phosphorylation of RPS6 proteinPMID:16033851 PMID:30641053
Rps6multiple interactionsISORPS6 (Homo sapiens)6480464CTD3,3'-diindolylmethane promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of RPS6 mRNA]PMID:11179685 PMID:16033851 PMID:30641053
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