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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbincreases expressionISORarb (Mus musculus)6480464CTDFenretinide results in increased expression of RARB mRNAPMID:28973697
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDFenretinide results in increased expression of RARB mRNA; Fenretinide results in increased expression of RARB proteinPMID:15375546 PMID:21319187
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTDFenretinide promotes the reaction [scriptaid results in increased expression of RARB mRNA]; Fenretinide promotes the reaction [trichostatin A results in increased expression of RARB mRNA]; RARB protein promotes the reaction [Fenretinide promotes the reaction [scriptaid results in increased expression of NR4A1 protein]]; RARB protein promotes the reaction [Fenretinide promotes the reaction [trichostatin A results in increased expression of NR4A1 protein]]; RARB protein promotes the reaction [Fenretinide results in increased expression of NR4A1 protein]; scriptaid promotes the reaction [Fenretinide results in increased expression of RARB mRNA]; trichostatin A promotes the reaction [Fenretinide results in increased expression of RARB mRNA]PMID:21319187
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