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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3461
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pygm
Name: glycogen phosphorylase, muscle associated
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pygmdecreases expressionISOPYGM (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of PYGM mRNAPMID:26537877 PMID:28940058 PMID:29803840 PMID:30031762
Pygmincreases expressionISOPygm (Mus musculus)6480464CTDDoxorubicin results in increased expression of PYGM proteinPMID:21251210
Pygmmultiple interactionsISOPygm (Mus musculus)6480464CTDsodium nitrate inhibits the reaction [Doxorubicin results in increased expression of PYGM protein]PMID:21251210
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