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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:64017
Term: (5Z,8Z,11Z,13E)-15-HETE
Definition: A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.
Chemical ID: MESH:C025984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcaaffects localizationISOPRKCA (Homo sapiens)6480464CTD15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the localization of PRKCA proteinPMID:15613483
Prkcaincreases activityISOPrkca (Mus musculus)6480464CTD15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA proteinPMID:15451026
Prkcamultiple interactionsISOPRKCA (Homo sapiens)6480464CTD15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [EGF protein affects the localization of PRKCA protein]; 15-hydroxy-5,8,11,13-eicosatetraenoic acid promotes the reaction [HGF protein affects the localization of PRKCA protein]PMID:15613483
Prkcamultiple interactionsISOPrkca (Mus musculus)6480464CTDcalphostin C inhibits the reaction [15-hydroxy-5,8,11,13-eicosatetraenoic acid results in increased activity of PRKCA protein]PMID:15451026
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