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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3395
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkca
Name: protein kinase C, alpha
Acc ID: CHEBI:4948
Term: Evodiamine
Definition: A beta-carboline that has formula C19H17N3O.
Chemical ID: MESH:C049639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcaincreases phosphorylationISOPrkca (Mus musculus)6480464CTDevodiamine results in increased phosphorylation of PRKCA proteinPMID:19854188
Prkcamultiple interactionsISOPrkca (Mus musculus)6480464CTDEGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]PMID:19854188
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