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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
Acc ID: CHEBI:34385
Term: 4-aminopyridine
Definition: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Chemical ID: MESH:D015761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkacaincreases phosphorylationEXP 6480464CTD4-Aminopyridine results in increased phosphorylation of PRKACA proteinPMID:35643327
Prkacamultiple interactionsEXP 6480464CTDlappaconitine inhibits the reaction [4-Aminopyridine results in increased phosphorylation of PRKACA protein]PMID:35643327
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