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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2caaffects expressionISOPpp2ca (Mus musculus)6480464CTDAcetaminophen affects the expression of PPP2CA mRNAPMID:17562736
Ppp2caincreases expressionISOPPP2CA (Homo sapiens)6480464CTDAcetaminophen results in increased expression of PPP2CA proteinPMID:22230336
Ppp2camultiple interactionsISOPPP2CA (Homo sapiens)6480464CTDPPP2CA protein affects the reaction [Acetaminophen affects the localization of CTNNB1 protein]; PPP2CA protein affects the reaction [Acetaminophen results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2CA protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 protein]PMID:30567741
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