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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3380
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppp2ca
Name: protein phosphatase 2 catalytic subunit alpha
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppp2camultiple interactionsEXP 6480464CTDPPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; PPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; PPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK3 protein modified form]; PPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; PPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; PPP2CA protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]PMID:19038359
Ppp2cadecreases expressionISOPPP2CA (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of PPP2CA mRNAPMID:31521693
Ppp2camultiple interactionsISOPPP2CA (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA]PMID:31521693
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