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GENE - TERM ANNOTATION REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: DOID:9003936
Term: Cardiomegaly
Definition: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Definition Source(s): MESH:D006332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomc ISOPOMC (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:1965992 PMID:2821097 PMID:6088243 PMID:8279378 PMID:8381257 PMID:19039989
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