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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcdecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of POMC mRNA; Dexamethasone results in decreased expression of POMC proteinPMID:32445661
Pomcmultiple interactionsEXP 6480464CTDMifepristone inhibits the reaction [Dexamethasone results in decreased expression of POMC mRNA]PMID:32445661
Pomcaffects response to substanceISOPOMC (Homo sapiens)6480464CTDPOMC affects the susceptibility to DexamethasonePMID:1459535
Pomcdecreases expressionISOPOMC (Homo sapiens)6480464CTDDexamethasone results in decreased expression of POMC proteinPMID:174842
Pomcdecreases secretionISOPOMC (Homo sapiens)6480464CTDDexamethasone results in decreased secretion of POMC proteinPMID:9253312
Pomcmultiple interactionsISOPOMC (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [Crack Cocaine results in increased secretion of POMC protein]; Dexamethasone inhibits the reaction [POMC protein results in increased abundance of Aldosterone]PMID:10780258 PMID:3015796
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