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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3361
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pnmt
Name: phenylethanolamine-N-methyltransferase
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pnmtincreases expressionEXP 6480464CTDNicotine results in increased expression of PNMT proteinPMID:29246838
Pnmtmultiple interactionsEXP 6480464CTDimidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]PMID:29246838
Pnmtincreases expressionISOPNMT (Homo sapiens)6480464CTDNicotine results in increased expression of PNMT mRNAPMID:17498763
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